cardiac myosins การใช้

• The first genetic mutation ( in cardiac myosin binding protein C ) responsible for feline HCM was discovered in 2005 in Maine Coon cats.
• Approximately 45 % of these mutations occur in the ? myosin heavy chain gene on chromosome 14 q11.2-3, while approximately 35 % involve the cardiac myosin binding protein C gene.
• Phosphorylation of cardiac myosin heavy chains ( see MYH7B ) and light chains ( see MYL2 ) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.
• Although he and his team were unable to establish the precise function of regulatory light chains in vertebrate skeletal and cardiac myosins, it laid the foundation for a whole new field of regulation of how phosphorylation regulates movement in smooth muscle and in non-muscle cells.
• The cardiac myosin binding protein C mutation identified in Maine Coon cats has not been found in any other breed of cat with HCM, but more recently another myosin binding protein C mutation has been identified in Ragdoll cats with HCM . As in humans, feline HCM is not present at birth but develops over time.
• Kayvanpour et al . performed 2016 a meta-analysis with the largest dataset available on genotype-phenotype associations in DCM and mutations in lamin ( LMNA ), phospholamban ( PLN ), RNA Binding Motif Protein 20 ( RBM20 ), Cardiac Myosin Binding Protein C ( MYBPC3 ), Myosin Heavy Chain 7 ( MYH7 ), Cardiac Troponin 2 ( TNNT2 ), and Cardiac Troponin I ( TNNI3 ).